regional medical center: Critical To The Control Of Influenza Are Both Innate And Adaptive Immune Responses

Minggu, 01 Juli 2012

Critical To The Control Of Influenza Are Both Innate And Adaptive Immune Responses

Critical To The Control Of Influenza Are Both Innate And Adaptive Immune Responses

Main Category: Flu / Cold / SARS
Also Included In: Immune System / Vaccines
Article Date: 01 Jul 2012 - 0:00 PDT

email to a friend Â

printer friendly Â

opinions Â <!--

rate article
Patient / Public: not yet rated

Healthcare Prof: not yet rated

Both innate and adaptive immune responses play an important role in controlling influenza virus infection, according to a study, published in the Open Access journal PLoS Computational Biology, by researchers from Oakland University, Michigan, and Los Alamos National Laboratory, New Mexico, USA.

Influenza, as a contagious respiratory illness remains a major public health problem worldwide. Seasonal and pandemic influenza results in approximately 3 to 569 million cases of severe illness and approximately 250,000 to 500,000 deaths worldwide. Although most infected subjects with intact immune systems are able to clear the virus without developing serious flu complications, the biological factors responsible for viral control remain unclear.

To investigate the factors for viral control, the researchers developed mathematical models that included both innate and adaptive immune responses to the virus. These models were used to study the viral dynamics of the influenza virus infection in horses. After infection, viral levels rise rapidly, reach a peak and fall, then they attain a low plateau that can be followed in some animals by a second peak. Ultimately, viral levels decline and the infection is cleared. By comparing modeling predictions with experimental data, researchers examined the relative roles of availability of cells susceptible to infection, so-called target cells, and innate and adaptive immune responses in controlling the virus.

The research showed that the two-part innate immune response, generated by natural killer cells, and the antiviral effect caused by interferon, a naturally produced protective molecule, can explain the first rapid viral decline and subsequent second viral peak. The second peak comes about because as the viral level falls, the immune response also falls allowing the virus the opportunity to grow back before the adaptive ultimately clears it.

However, for eventual viral clearance it is the body's adaptive immune response that is needed.

The data analyzed were from equine influenza virus infection in horses. However, similar viral kinetic profiles have been observed in humans infected with the influenza virus. The authors conclude that the study can be used to explain the viral and interferon kinetics observed during a typical influenza virus infection.

Additional

References

Citations

Financial disclosure: Portions of this work were done under the auspices of the US Department of Energy under contract DE-AC52-06NA25396, supported by the NIH grant P30-EB011339 and contract HHSN272201000055C, the National Center for Research Resources and the Office of Research Infrastructure Programs (ORIP) through grant 8R01-OD011095-21, NSF grants DMS-1122290 and PHY-0551164, and the Los Alamos National Laboratory LDRD Program. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. Competing interests: The authors have declared that no competing interests exist. Citation: Pawelek KA, Huynh GT, Quinlivan M, Cullinane A, Rong L, et al. (2012) Modeling Within-Host Dynamics of Influenza Virus Infection Including Immune Responses. PLoS Comput Biol 8(6): e1002588. doi:10.1371/journal.pcbi.1002588
Public Library of Science Please use one of the following formats to cite this article in your essay, paper or report:

MLA

APA

Please note: If no author information is provided, the source is cited instead.

Add Your Opinion On This Article

'Critical To The Control Of Influenza Are Both Innate And Adaptive Immune Responses'

Please note that we publish your name, but we do not publish your email address. It is only used to let you know when your message is published. We do not use it for any other purpose. Please see our privacy policy for more information.

If you write about specific medications or operations, please do not name health care professionals by name.

All opinions are moderated before being included (to stop spam)

Contact Our News Editors

For any corrections of factual information, or to contact the editors please use our feedback form.

Please send any medical news or health news press releases to:

Note: Any medical information published on this website is not intended as a substitute for informed medical advice and you should not take any action before consulting with a health care professional. For more information, please read our terms and conditions.

regional medical center

Minggu, 01 Juli 2012

Critical To The Control Of Influenza Are Both Innate And Adaptive Immune Responses

Add Your Opinion On This Article

Tidak ada komentar:

Posting Komentar